This chapter focuses on the effectiveness of region-wide governance. The region faces challenges associated with articulating and implementing region-wide plans to address workforce development, innovation capacity, transportation and logistics and green growth. At issue is how to go about developing and implementing these action plans effectively, and how to monitor progress and measure success over time. Main challenges include institutional fragmentation and the region’s limited capacity to think and act regionally. These challenges make interstate, region-wide co-ordination difficult, leaving little energy or political capital for focusing on long-term issues. These challenges hinder the ability to appreciate the true nature of the region’s competitors, both international and domestic. This chapter proposes a road map to encourage more effective, on-going Tri-State collaboration to drive growth.