This chapter analyses the main trends, challenges and opportunities in the Hamburg Metropolitan Region (referred to as HMR for short), with a particular focus on three dimensions: i) economic performance, innovation and digitalisation; ii) quality of life, transport, housing, environmental sustainability and tourism; and iii) the institutional framework. In doing so, the chapter benchmarks the HMR with all other metropolitan regions in Germany and with carefully selected, comparable metropolitan regions across OECD countries.