Mobilising additional resources for health financing in Latin America and the Caribbean (LAC) is necessary to achieve high-quality universal health coverage. However, LAC countries must balance investments in their health systems with other needs in a context of limited public funding and competing priorities. This chapter focuses on the importance of reducing wasteful expenditures particularly in the areas of clinical care, operational and governance waste, as a way to accelerate the path towards universal health coverage. Addressing waste in health systems entails reviewing structures, regulations, services and processes that are either harmful or do not deliver expected benefits, as well as costs that could be avoided by substituting cheaper alternatives with comparable or superior benefits. Policy-makers and managers in LAC should consider such waste-reduction initiatives as tools at their disposal to build higher quality and more sustainable health systems. In the LAC region, spending better on health is as important as spending more. Without cutting budgets and even in a scenario of increasing government health expenditure, being more efficient and achieving better results for more people can be a self-reinforcing strategy, if properly designed so as to be synergic.