The 2022 edition of Health at a Glance: Europe examines the key challenges European countries must address to develop stronger, more resilient health systems following the acute phase of the COVID-19 pandemic. It includes a special focus on how the pandemic has affected young people’s mental and physical health. The report emphasises the need for additional measures to prevent the COVID-19 pandemic from scarring a generation of young people. This edition of Health at a Glance: Europe also assesses the pandemic’s disruption of a wide range of health services for non-COVID patients, as well as the policy responses European countries deployed to minimise the adverse consequences of these disruptions. It also addresses a number of important behavioural and environmental risk factors that have a major impact on people’s health and mortality, highlighting the need to put a greater focus on the prevention of both communicable and non-communicable diseases.