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Endocrine Disrupters – Combination effects

image of Endocrine Disrupters – Combination effects

During the 2010 Danish Presidency of the Nordic Council of Ministers environment and health was a prioritized subject. The aim was enhanced Nordic information exchange. To support this aim a number of Nordic workshops were held to strengthen the capacity building and discuss future regulatory aspects in the area of endocrine disruptors, combination effects, and soft regulatory measures and effective risk communication. One of the workshops held in November focused on combination effects, with a special focus on endocrine disruptors. This report describes the workshop presentations, the ensuing discussions, and the outcome.

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Workshop session 3: Risk assessment factors across legislations and exposure knowledge

It was agreed that combination effects could be addressed in human health risk assessment and environmental risk assessment by allowing that each substance could only contribute with a maximum of 10% to the total risk (i.e. a maximum Risk Characterisation Ratio of 0.1) or by introducing an extra Mixture Assessment Factor (MAF) of e.g. 10 for human health risk assessment and 100 for environmental risk assessment. It was also generally agreed that allocation of a certain fraction of the maximum permissible exposure to the individual regulatory schemes could be a way of preventing risk from the cumulative exposure to substances from sources regulated under different sector specific legislations, e.g. for food, water and environment. In food for instance, the maximum residual level for ED could be set at a certain fraction (e.g. 10%) of the Acceptable Daily Intake to take into account possible contributions from other sources.

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