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Safety Assessment of Transgenic Organisms, Volume 2

OECD Consensus Documents

image of Safety Assessment of Transgenic Organisms, Volume 2

These OECD Biosafety Consensus Documents identify elements of scientific information used in the environmental safety and risk assessment of transgenic organisms which are common to OECD member countries.  This is intended to encourage information sharing and prevent duplication of effort among countries. This book offers ready access to those consensus documents which have been published thus far. As such, it should be of value to applicants for commercial uses of transgenic crops, regulators in national authorities as well as the wider scientific community. More information on the OECD's work related to the biosafety of transgenic organisms is found at BioTrack Online (http://www.oecd.org/biotrack).

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Section 1 - Baculoviruses

Baculoviuses are a family of arthropod-specific, rod-shaped (baculum = rod), enveloped viruses with a circular double-stranded DNA genome. Until recently, the family Baculoviridae was divided into two subfamilies, the Eubaculovirinae and the Nudibaculovirinae (Francki et al., 1991). Based on the type of virion occlusion (see below) the Eubaculovirinae comprised the genera (i) nuclear polyhedrosis virus (NPV) and (ii) granulovirus (GV). The subfamily Nudibaculovirinae contained the only genus non-occluded baculovirus (NOB) which differed from the Eubaculovirinae in the lack of occlusion body formation and virion morphology (for review see Burand, 1991).

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