Pharmacogenetics: Opportunities and Challenges for Health Innovation

image of Pharmacogenetics: Opportunities and Challenges for Health Innovation

Pharmacogenetics helps us understand the relationship between an individual’s genetic make-up and the way medicines work for each person. This book reviews the use of pharmacogenetics across all stages of the health innovation cycle from research through to uptake by doctors and patients. It focuses on how to optimise the use of pharmacogenetics to deliver effective innovations for public health, and design policies that enhance their economic and social benefits. The book argues for large-scale studies to validate the biomarkers that underpin pharmacogenetics and policies to share the cost and risk of using  pharmacogenetics to improve the use of existing  medicines. Governments and others need to align regulatory, reimbursement and other incentives and work  with industry to measure better the impacts of pharmacogenetics. Health systems need to take positive steps to adapt to the use of pharmacogenetics and ensure that health professionals receive adequate training.


Pharmacogenetics and Drug Development

This chapter examines the application of pharmacogenetics to drug development. It explains why there has been a recent slowdown in discovery and development of new medicines and how pharmacogenetics may help address this problem. It discusses how application of genetic biomarkers will affect drug development. Such an approach can, in principle, reduce the costs of clinical trials for prospective medicines while increasing the probability that potential products might reach the market.


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