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Pharmacogenetics: Opportunities and Challenges for Health Innovation

image of Pharmacogenetics: Opportunities and Challenges for Health Innovation

Pharmacogenetics helps us understand the relationship between an individual’s genetic make-up and the way medicines work for each person. This book reviews the use of pharmacogenetics across all stages of the health innovation cycle from research through to uptake by doctors and patients. It focuses on how to optimise the use of pharmacogenetics to deliver effective innovations for public health, and design policies that enhance their economic and social benefits. The book argues for large-scale studies to validate the biomarkers that underpin pharmacogenetics and policies to share the cost and risk of using  pharmacogenetics to improve the use of existing  medicines. Governments and others need to align regulatory, reimbursement and other incentives and work  with industry to measure better the impacts of pharmacogenetics. Health systems need to take positive steps to adapt to the use of pharmacogenetics and ensure that health professionals receive adequate training.

English

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Executive Summary

Pharmacogenetics offers new ways of understanding how drugs work and how this affects both the safety and efficacy of drugs in individuals. The potential opportunities are considerable. In drug development, pharmacogenetics shows great potential for improving the efficiency of the drug discovery process, particularly for identifying and validating new drug targets. It is expected to improve the translation of early-stage projects into medicines that meet public health needs. In clinical care, pharmacogenetics may enable doctors to prescribe more effective interventions and improve their use of evidence-based medicine. It can help identify those individuals most likely to benefit from a therapy, thereby optimising treatment strategies for both common and complex disorders. It may also enable preventive interventions.

English

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