The regulatory framework that applies to internal government activities – regulation inside government – should promote efficiency and effectiveness in the delivery of public outputs and in the design and implementation of public policies. When properly designed, regulation inside government helps to advance accountability and transparency and prevent corruption. In contrast, when regulation inside government generates bureaucratic processes, scarce taxpayer funds are directed to complying with burdensome requirements. As part of its strategy to make the public administration more effective and efficient, the Mexican Government led an exercise to review the stock of internal regulations; by the beginning of 2011, this exercise had resulted in the elimination of 67% of the internal regulatory instruments and in the elaboration and publication of 9 administrative handbooks for general application to the internal activities of the government. This chapter explains and evaluates this exercise in light of international experiences and proposes recommendations to consolidate results and ensure a lasting impact.