International co-operation plays an important role in comprehensive civil protection as risks do not stop at borders. This chapter examines the foundations for international co-operation in the Mexican National Civil Protection System. It identifies good practices in cross border co-operation between Mexico and its neighbouring countries in areas such as risk prevention, data sharing for the operation of early warning systems and preparation with joint training and exercises. It also considers co-operation in the broader international context of the provision, receipt and distribution of humanitarian assistance to and from other countries in the immediate aftermath of a disaster and the emerging role of Mexico as a donor of humanitarian assistance.