Safety Assessment of Transgenic Organisms in the Environment, Volume 8

OECD Consensus Document of the Biology of Mosquito Aedes aegypti

image of Safety Assessment of Transgenic Organisms in the Environment, Volume 8

Volume 8 of the Series contains the first biosafety ‘consensus document’ to deal with the biology of an insect, the mosquito Aedes aegypti. Issued by the OECD Working Group on the Harmonisation of Regulatory Oversight in Biotechnology, the science-based consensus documents collate information for use during the regulatory risk assessment of biotechnology products, i.e. transgenic organisms (plants, animals, micro-organisms) when intended for release in the environment. Ae. aegypti mosquito is vectoring yellow fever, dengue, Zika and Chikungunya diseases in tropical and sub-tropical regions worldwide. Biotechnological applications are developed to control the mosquito population and reduce virus transmission. The book provides information on Ae. aegypti taxonomy, morphology, life cycle, reproductive biology, genetics, ecology, interactions with other species and the environment. The mosquito effects on human and animal health, and the control strategies/specific programmes to limit its development are also summarised.



Genetics of the mosquito Ae. aegypti

This chapter deals with the genetics of Aedes aegypti, including genetic linkage to the physical map of the mosquito genome, its population genetics and its geographic distribution (phylogeography). Information is then provided on the genetics of insecticide susceptibility, the diverse modes of action and mechanisms of resistance to insecticides (metabolic, target-site, reduced penetration, behavioural avoidance). The last section focuses on the genetics of vector competence in Ae. aegypti, comprising the susceptibility of the mosquito populations to viruses and dengue virus in particular, the anatomic barriers to infection (midgut cells), the climatic factors affecting the infection susceptibility, the genetic variability and geographical variations in Ae. aegypti vector competence.


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