OECD iLibrary | OECD Series on Adverse Outcome Pathways

OECD Series on Adverse Outcome Pathways

An Adverse Outcome Pathway (AOP) describes a logical sequence of causally linked events at different levels of biological organisation, which follows exposure to a chemical and leads to an adverse health effect in humans or wildlife. AOPs are the central element of a toxicological knowledge framework, promoted by member countries through OECD, built to support chemical risk assessment based on mechanistic reasoning. These AOPs are available in the AOP Wiki, an interactive and virtual encyclopaedia for AOP development. Following their development and review, the endorsed AOPs are published the OECD Series on Adverse Outcome Pathways. As scientific knowledge progresses, the publication of an AOP in this series does not preclude the regular update or new contributions to a given AOP in the AOP Wiki. While the AOP Wiki is a dynamic tool, only impactful changes to the AOP will be reflected in subsequent updates of the published AOP. The number 1 in the OECD Series on Adverse Outcome Pathways is the Users’ Handbook, which is a supplement to the Guidance Document for developing and assessing AOPs. This handbook contains an updated template for AOP development and provides focused and practical instructions for both AOP developers and reviewers.

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ISSN: 2415170X (online)
https://doi.org/10.1787/2415170X

9 results

	Date Date	Title Title	Click to Access
No. 9	12 Oct 2018	Adverse Outcome Pathway on Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve This AOP details the linkage between binding and activation of androgen receptor (AR) in females and reductions in cumulative fecundity and spawning. AR-mediated activities are among the major concerns in endocrine disruptor screening programs....	Click to download PDF - 577.15KB PDF Click to Read online and share READ
No. 8	12 Oct 2018	Adverse Outcome Pathway on chronic binding of antagonist to N-methyl-D-aspartate receptors during brain development leading to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet and Rex FitzGerald This AOP links chronic NMDA receptors inhibition during brain development to neurodegeneration in hippocampus and cortex with amyloid plaque deposition and tau hyperphosphorylation, and impairment of learning and memory, which are considered as...	Click to download PDF - 6.40MB PDF Click to Read online and share READ
No. 7	12 Oct 2018	Adverse Outcome Pathway on Inhibition of the mitochondrial complex I of nigro-striatal neurons leading to parkinsonian motor deficits Anna Bal-Price, Marcel Leist, Stefan Schildknecht, Florianne Tschudi-Monnet, Alicia Paini and Andrea Terron This AOP describes the linkage between inhibition of complex I (CI) of the mitochondrial respiratory chain and motor deficit as in parkinsonian disorders. Binding of an inhibitor to CI has been defined as the molecular initiating event (MIE) that...	Click to download PDF - 577.15KB PDF Click to Read online and share READ
No. 6	09 Sep 2016	Adverse Outcome Pathway on binding of agonists to ionotropic glutamate receptors in adult brain leading to excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment Magdalini Sachana, Sharon Munn and Anna Bal-Price Under physiological conditions activation of glutamate ionotropic receptors such as N-methyl-D-aspartate (NMDARs), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPARs) and kainate (KARs) is responsible for basal excitatory synaptic...	Click to download PDF - 1.45MB PDF Click to Read online and share READ
No. 5	13 Aug 2016	Adverse Outcome Pathway on chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Magdalini Sachana, Sharon Munn and Anna Bal-Price It is well documented and accepted that learning and memory processes rely on physiological functioning of the glutamate receptor N-methyl-D-aspartate (NMDAR). Both animal and human studies investigating NMDA itself, experiments with NMDAR...	Click to download PDF - 1.45MB PDF Click to Read online and share READ
No. 4	06 Aug 2016	Adverse Outcome Pathway on Aromatase Inhibition Leading to Reproductive Dysfunction (in Fish) Dan Villeneuve This adverse outcome pathway details the linkage between inhibition of gonadal aromatase activity in females and reproductive dysfunction, as measured through the adverse effect of reduced cumulative fecundity and spawning. Initial development of...	Click to download PDF - 1.45MB PDF Click to Read online and share READ
No. 3	04 Aug 2016	Adverse Outcome Pathway on Alkylation of DNA in Male Pre-Meiotic Germ Cells Leading to Heritable Mutations Carole Yauk, Iain Lambert, Francesco Marchetti and George Douglas Germ cell/heritable mutations are important regulatory endpoints for international agencies interested in protecting the health of future generations. However, germ cell mutation analysis has been hampered by a lack of efficient tools. The motivation...	Click to download PDF - 1.45MB PDF Click to Read online and share READ
No. 2	04 Aug 2016	Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis Brigitte Landesmann Liver fibrosis is an important human health issue associated with chemical exposure. It is a typical result of chronic toxic injury and one of the considered endpoints for regulatory purposes. This AOP describes the linkage between hepatic injury...	Click to download PDF - 1.45MB PDF Click to Read online and share READ
No. 1	14 Feb 2018	Users' Handbook supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways This document is a supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways (AOPs). It provides focused and practical instructions for both AOP developers and reviewers and is intended to assist in identifying,...	Click to download PDF - 313.10KB PDF Click to Read online and share READ

9 results

Adverse Outcome Pathway on Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
Dan Villeneuve
12 Oct 2018

This AOP details the linkage between binding and activation of androgen receptor (AR) in females and reductions in cumulative fecundity and spawning. AR-mediated activities are among the major concerns in endocrine disruptor screening programs....

Adverse Outcome Pathway on chronic binding of antagonist to N-methyl-D-aspartate receptors during brain development leading to neurodegeneration with impairment in learning and memory in aging
Florianne Tschudi-Monnet and Rex FitzGerald
12 Oct 2018

This AOP links chronic NMDA receptors inhibition during brain development to neurodegeneration in hippocampus and cortex with amyloid plaque deposition and tau hyperphosphorylation, and impairment of learning and memory, which are considered as...

Adverse Outcome Pathway on Inhibition of the mitochondrial complex I of nigro-striatal neurons leading to parkinsonian motor deficits
Anna Bal-Price, Marcel Leist, Stefan Schildknecht, Florianne Tschudi-Monnet, Alicia Paini and Andrea Terron
12 Oct 2018

This AOP describes the linkage between inhibition of complex I (CI) of the mitochondrial respiratory chain and motor deficit as in parkinsonian disorders. Binding of an inhibitor to CI has been defined as the molecular initiating event (MIE) that...

Adverse Outcome Pathway on binding of agonists to ionotropic glutamate receptors in adult brain leading to excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment
Magdalini Sachana, Sharon Munn and Anna Bal-Price
09 Sep 2016

Under physiological conditions activation of glutamate ionotropic receptors such as N-methyl-D-aspartate (NMDARs), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPARs) and kainate (KARs) is responsible for basal excitatory synaptic...

Adverse Outcome Pathway on chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
Magdalini Sachana, Sharon Munn and Anna Bal-Price
13 Aug 2016

It is well documented and accepted that learning and memory processes rely on physiological functioning of the glutamate receptor N-methyl-D-aspartate (NMDAR). Both animal and human studies investigating NMDA itself, experiments with NMDAR...

Adverse Outcome Pathway on Aromatase Inhibition Leading to Reproductive Dysfunction (in Fish)
Dan Villeneuve
06 Aug 2016

This adverse outcome pathway details the linkage between inhibition of gonadal aromatase activity in females and reproductive dysfunction, as measured through the adverse effect of reduced cumulative fecundity and spawning. Initial development of...

Adverse Outcome Pathway on Alkylation of DNA in Male Pre-Meiotic Germ Cells Leading to Heritable Mutations
Carole Yauk, Iain Lambert, Francesco Marchetti and George Douglas
04 Aug 2016

Germ cell/heritable mutations are important regulatory endpoints for international agencies interested in protecting the health of future generations. However, germ cell mutation analysis has been hampered by a lack of efficient tools. The motivation...

Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis
Brigitte Landesmann
04 Aug 2016

Liver fibrosis is an important human health issue associated with chemical exposure. It is a typical result of chronic toxic injury and one of the considered endpoints for regulatory purposes. This AOP describes the linkage between hepatic injury...

Users' Handbook supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways

14 Feb 2018

This document is a supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways (AOPs). It provides focused and practical instructions for both AOP developers and reviewers and is intended to assist in identifying,...

Discontinued Series