Co-ordination between the various stakeholders involved in policy design and policy implementation is critical to avoid duplications, harness synergies between programmes, and make sure that policy gaps are minimised. Co-ordination is especially important in the case of small and medium-sized enterprise (SME) and entrepreneurship policies, as they often fall under the remit of both national and sub‐national governments and cut across the responsibilities of different ministries. This chapter examines the national factors that set the context for policy co-ordination and tailoring, and identifies how the right governance mechanisms, delivery arrangements, and data collection and evaluation can improve the implementation of these policies.