The results from a survey of 34 Latin American universities and a series of interviews with experts in higher education shed light on recent trends in e-learning in the region. While e-learning has increased and is expected to grow, the face-to-face model is still predominant and different challenges remain. Access has expanded for certain groups, but the digital gap is still large. Efforts need to be made in areas such as accreditation, evaluation and teachers’ training to improve and maintain quality in emerging modalities of e-learning. The focus of e-learning programmes is still not well linked with labour market demands and the costs of setting up, developing and maintaining e-learning platforms are high. Policies are needed to tap the potential of e-learning. More flexible and enabling regulations, larger public involvement and public-private partnerships for financing, and better teacher training are essential according to the results from the interviews.