This chapter examines federal, regional and local policies and institutions for regional development in Chihuahua. It starts by discussing the institutional framework – the international context being a border region, as well as the federal, state and municipal levels of government – in Chihuahua. The chapter continues with an analysis of the policies in place and points at the need for reforms to enhance economic growth. In particular, the chapter looks at policies for private-sector development: i) those that aim at fostering private investment, ii) those for upgrading the regulatory framework, and iii) cluster policies to link value chains. One of the central policy discussions in this chapter is the policy options that the state has, in order to strike a balance between attracting foreign direct investment and supporting local entrepreneurship. The chapter also looks at policies to develop and attract skills and talent, as well as innovation policies such as science and technology parks, the financing of innovation and the institutions for innovation. In light of Chihuahua’s vulnerability to external shocks, one of the policy options that are explored is the diversification of the economy in sectors with growth potential. The chapter ends with a discussion on the potential role of a regional development agency in Chihuahua that would allow a quadruplehelix approach to regional development with the implied involvement of the private sector, academia and civil society.