Novel Systems for the Study of Human Disease

Novel Systems for the Study of Human Disease

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Author(s):
OECD
06 Feb 1998
Pages:
400
ISBN:
9789264162389 (PDF) ;9789264160118(print)
http://dx.doi.org/10.1787/9789264162389-en

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Transgenic mice have become of central importance for basic biological research, and for understanding diseases involving malfunction of the genetic machinery. The value of these animals as research tools may extend far beyond the purposes of the research project for which they were generated. Their documentation and conservation -- as live animals, embryos or gametes (eggs or sperm) -- therefore becomes of high importance. This proceedings brings together scientific papers covering the breadth and significance of model animals used in scientific research, and scientific and policy summaries based on workshop discussions.
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Table of Contents

EXECUTIVE SUMMARY
SCIENTIFIC SUMMARY
OPENING SPEECHES BY HOST COUNTRY
INTRODUCTION
-Gene targeting: an historical perspective by M. Capecchi, United States
-Somatic gene therapy: from basic science to clinical applications by S. Woo, United States
CURRENT DEVELOPMENTS IN THE TECHNOLOGY
-Conditional gene targeting by K. Rajewsky, Germany
-Engineering chromosomes in mice to facilitate the identification of tumour suppressor genes by A. Bradley, United States
-The use of genetic switches for the generation of conditional mutants at the level of cells and animals by H. Bujard, Germany
-Yeast Artificial Chromosomes as vectors for transgenesis by G. Schütz, Germany
-We need more mutants: plans for a large scale ENU mouse mutagenesis screen by R. Balling, Germany
INTERNATIONAL FACILITIES AND INFRASTRUCTURE
-The Jackson Laboratory: research to resource by B. Knowles, United States
-The European Mouse Mutant Archive (EMMA) by P. Rigby, United Kingdom
Supporting transgenic research: repositories and distribution – the CDTA experience by C. Benoist, France
-Rapid and efficient embryo manipulation systems by using cryopreserved mouse embryos, oocytes, and sperm" (Abstract) by M. Katsuki, Japan
GENERAL DISCUSSION SESSION I: CURRENT DEVELOPMENTS IN THE TECHNOLOGY and INTERNATIONAL FACILITIES AND INFRASTRUCTURES
FIELDS OF APPLICATION
-Diabetes mellitus – use of transgenic technology to study both the pathophysiological mechanisms of the disease and new therapies by F. Bosch, Spain
-The obese gene: an invaluable chance to explore the mechanisms which regulate body weight by M. Maffei, Italy
-Cystic Fibrosis – an example of modelling a monogenic disease in the mouse by J. Dorin, United Kingdom
-Lessons from the Rb mutant mouse by T. Jacks, United States
-The use of transgenic, knock-out and interspecific hybrid mice in studies of cancer predisposition and tumour progression by A. Balmain, United Kingdom
-Oncogene function in normal development and disease by E. Wagner, Austria
-The construction and use of HIV-1 transgenic mice in AIDS research by M. Martin, United States
-Insights into the ontogeny and activation of T cells in mutant mice by T.W. Mak, Canada
-Targeted deficiency in the mouse HOXD complex: compound digit defects as a model for the human synpolydactyly syndrome by D. Duboule, Switzerland
-Transgenic mouse models for skeletal diseases (including osteoporosis and osteoarthritis) by E. Vuorio, Finland
-An experiment-based classification of blood pressure genes by J. Krege, United States
-The use of transgenic mice in the investigation of transmissible Spongiform Encephalopathies by C. Weissmann, Switzerland
-Transgenic animal models of Alzheimer’s disease pathology by B. Cordell, United States
-Transgenic mouse models for Alzheimer’s disease by F. van Leuven, Belgium
-Skeletal myogenesis: from determination to therapy G. Cossu, Italy
-Vaccine development and testing: review by M. De Wilde, Belgium
-The transgenic mouse model of poliovirus by P. Minor, United Kingdom
POLICY ASPECTS AND DISCUSSION
-Cryopreservation centres: the means to an archive by L. Mobraaten, United States
-Towards a central repository of data on transgenic animals and targeted mutations by A. Anagnostopoulos, United States
-Drug testing, quality control, and standards by J. Purves, United KingdomGENERAL DISCUSSION SESSION II: FIELDS OF APPLICATION and POLICY ASPECTS AND DISCUSSION
-Transgenic models in drug discovery - an industrial perspective by P. Hardy, France
-Intellectual property aspects by K. Becker, Switzerland
PANEL DISCUSSION (SESSION III) AND CONCLUSIONS
ANNEX: FOLLOW-UP REGARDING INTELLECTUAL PROPERTY
LIST OF PARTICIPANTS

 
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