Mexico’s National Civil Protection System relies upon a comprehensive legal and regulatory framework. This chapter will discuss key examples of the progress made, highlighting the major achievements that underpin operational and strategic strengths of the system today, while also identifying opportunities for improvement. It discusses the challenges of co-ordination across the three levels of government as well as the institutional frameworks at local level. Finally, it analyses the opportunities offered by the new 2012 General Law for Civil Protection, as well as its implications in terms of challenges for implementation.