To assess the probability and consequence of future global shocks a better understanding is needed about where contagion effects and amplification are likely to occur. First, risk managers must identify the hubs of critical systems and resources, which if disrupted could trigger a series of adverse knock-on effects. They also need to investigate how dependency on a single or few critical resources or systems may create unexpected vulnerabilities to endogenous or exogenous shocks. In addition, risk managers should adopt a broader view of risk, beyond visible direct threats, and expand their situation awareness to include trends and events that take place in far away locations and identify components in critical systems that may amplify risks. This chapter focuses on the potential for global shocks resulting from the threats covered in the project’s case studies on pandemics, financial crises, cyber risks and geomagnetic storms. It draws general conclusions regarding the need to increase access to data and information resources in order to establish or reinforce systemic risk assessments.