OECD Guidelines for the Testing of Chemicals, Section 4

Health Effects

Test No. 489: In Vivo Mammalian Alkaline Comet Assay
Anglais
ISSN :
2074-5788 (en ligne)
DOI :
10.1787/20745788
Cacher / Voir l'abstract

The OECD Guidelines for the Testing of Chemicals is a collection of about 150 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of chemicals. They are a set of tools for professionals, used primarily in regulatory safety testing and subsequent chemical and chemical product notification, chemical registration and in chemical evaluation. They can also be used for the selection and ranking of candidate chemicals during the development of new chemicals and products and in toxicology research. This group of tests covers health effects.

Egalement disponible en: Français
 

Cacher / Cacher / Voir les résumés

Sélectionner Numéro Date TitreCliquez pour accéder
    26 sep 2014 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9714511e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-489-in-vivo-mammalian-alkaline-comet-assay_9789264224179-en
  • LIRE
Test No. 489: In Vivo Mammalian Alkaline Comet Assay
OCDE
The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.
    26 sep 2014 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9714521e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-431-in-vitro-skin-corrosion-reconstructed-human-epidermis-rhe-test-method_9789264224193-en
  • LIRE
Test No. 431: In Vitro Skin Corrosion: Reconstructed Human Epidermis (Rhe) Test Method
OCDE
This Test Guideline addresses the human health hazard endpoint skin corrosion, following exposure to a test chemical.
    26 sep 2014 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9714531e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-473-in-vitro-mammalian-chromosomal-aberration-test_9789264224223-en
  • LIRE
Test No. 473: In Vitro Mammalian Chromosomal Aberration Test
OCDE
This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
    26 sep 2014 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9714541e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-474-mammalian-erythrocyte-micronucleus-test_9789264224292-en
  • LIRE
Test No. 474: Mammalian Erythrocyte Micronucleus Test
OCDE
The mammalian in vivo micronucleus test detects damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals.
    26 sep 2014 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9714551e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-475-mammalian-bone-marrow-chromosomal-aberration-test_9789264224407-en
  • LIRE
Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test
OCDE
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters).
    26 sep 2014 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9714561e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-487-in-vitro-mammalian-cell-micronucleus-test_9789264224438-en
  • LIRE
Test No. 487: In Vitro Mammalian Cell Micronucleus Test
OCDE
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells.
    26 jui 2013 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9713201e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-430-in-vitro-skin-corrosion-transcutaneous-electrical-resistance-test-method-ter_9789264203808-en
  • LIRE
Test No. 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER)
OCDE
The present Test Guideline addresses the human health hazard endpoint skin corrosion, following exposure to a test chemical. Skin corrosion is defined as the production of irreversible tissue damage, manifested as visible necrosis of the skin ...
    26 jui 2013 Test No. 431: In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method
OCDE
The present Test Guideline addresses the human health hazard endpoint skin corrosion, following exposure to a test chemical. Skin corrosion is defined as the production of irreversible tissue damage, manifested as visible necrosis of the skin ...
    26 jui 2013 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9713221e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-437-bovine-corneal-opacity-and-permeability-test-method-for-identifying-i-chemicals-inducing-serious-eye-damage-and-ii-chemicals-not-requiring-classification-for-eye-irritation-or-serious-eye-damage_9789264203846-en
  • LIRE
Test No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage
OCDE
The Bovine Corneal Opacity and Permeability test method (BCOP) is an in vitro test method that can be used to identify chemicals (substances or mixtures) as either 1) causing "serious eye damage" (category 1 of the Globally Harmonised System for the ...
    26 jui 2013 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9713231e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-438-isolated-chicken-eye-test-method-for-identifying-i-chemicals-inducing-serious-eye-damage-and-ii-chemicals-not-requiring-classification-for-eye-irritation-or-serious-eye-damage_9789264203860-en
  • LIRE
Test No. 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage
OCDE
The Isolated Chicken Eye Test (ICE) Method is an in vitro test method that can be used to identify chemicals (substances or mixtures) as either 1) causing "serious eye damage" (category 1 of the Globally Harmonised System for the Classification and ...
    26 jui 2013 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9713241e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-439-in-vitro-skin-irritation-reconstructed-human-epidermis-test-method_9789264203884-en
  • LIRE
Test No. 439: In Vitro Skin Irritation - Reconstructed Human Epidermis Test Method
OCDE
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2 ...
    26 jui 2013 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9713251e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-488-transgenic-rodent-somatic-and-germ-cell-gene-mutation-assays_9789264203907-en
  • LIRE
Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays
OCDE
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...
    02 oct 2012 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9712201e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-405-acute-eye-irritation-corrosion_9789264185333-en
  • LIRE
Test No. 405: Acute Eye Irritation/Corrosion
OCDE
This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is ...
    02 oct 2012 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9712211e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-443-extended-one-generation-reproductive-toxicity-study_9789264185371-en
  • LIRE
Test No. 443: Extended One-Generation Reproductive Toxicity Study
OCDE
This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ...
    02 oct 2012 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9712221e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-455-performance-based-test-guideline-for-stably-transfected-transactivation-in-vitro-assays-to-detect-estrogen-receptor-agonists_9789264185388-en
  • LIRE
Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists
OCDE
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provides the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists (ER TAs). It comprises mechanistically and functionally similar test ...
    02 oct 2012 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9712231e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-457-bg1luc-estrogen-receptor-transactivation-test-method-for-identifying-estrogen-receptor-agonists-and-antagonists_9789264185395-en
  • LIRE
Test No. 457: BG1Luc Estrogen Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists and Antagonists
OCDE
This Test Guideline describes an in vitro assay, which provides concentration-response data for substances with in vitro ER agonist and antagonist activity. The test system utilises the BG1Luc4E2 cell line derived from a human ovarian adenocarcinoma ...
    02 oct 2012 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9712241e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-460-fluorescein-leakage-test-method-for-identifying-ocular-corrosives-and-severe-irritants_9789264185401-en
  • LIRE
Test No. 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants
OCDE
This Test Guideline describes an in vitro assay that may be used for identifying water soluble ocular corrosives and severe irritants as defined by the UN Globally Harmonized System of Classification and Labelling, Category 1. The assay is performed ...
    28 jui 2011 Test No. 443: Extended One-Generation Reproductive Toxicity Study
OCDE
This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ...
    28 jui 2011 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9745601e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-456-h295r-steroidogenesis-assay_9789264122642-en
  • LIRE
Test No. 456: H295R Steroidogenesis Assay
OCDE
This Test Guideline describes an in vitro screen for chemical effects on steroidogenesis, specifically the production of 17ß-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma cell line, used for the assay, expresses genes that ...
    28 jui 2011 Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays
OCDE
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...
    23 jui 2010 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9741701e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-417-toxicokinetics_9789264070882-en
  • LIRE
Test No. 417: Toxicokinetics
OCDE
This Test Guideline describes in vivo studies that provide information on mass balance, absorption, bioavailability, tissue distribution, metabolism, excretion, and basic toxicokinetic parameters [e.g. AUC], as well as supplemental approaches that ...
    23 jui 2010 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9742901e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-429-skin-sensitisation_9789264071100-en
  • LIRE
Test No. 429: Skin Sensitisation
OCDE
The basic principle underlying the Local Lymph Node Assay (LLNA) in mouse is that sensitizers induce a primary proliferation of lymphocytes in the auricular lymph nodes draining the site of chemical application. This proliferation is proportional to ...
    23 jui 2010 Test No. 439: In Vitro Skin Irritation
OCDE
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2 ...
    23 jui 2010 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9744201e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-442a-skin-sensitization_9789264090972-en
  • LIRE
Test No. 442A: Skin Sensitization
OCDE
The Local Lymph Node Assay: DA (LLNA: DA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular lymph nodes. The ...
    23 jui 2010 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9744211e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-442b-skin-sensitization_9789264090996-en
  • LIRE
Test No. 442B: Skin Sensitization
OCDE
The Local Lymph Node Assay: BrdU-ELISA (LLNA:BrdU-ELISA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular ...
    23 jui 2010 Test No. 487: In Vitro Mammalian Cell Micronucleus Test
OCDE
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells. Micronuclei may originate from acentric chromosome fragments (i.e. lacking a centromere), or whole chromosomes that are ...
    08 sep 2009 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9740301e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-403-acute-inhalation-toxicity_9789264070608-en
  • LIRE
Test No. 403: Acute Inhalation Toxicity
OCDE
This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...
    08 sep 2009 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9741201e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-412-subacute-inhalation-toxicity-28-day-study_9789264070783-en
  • LIRE
Test No. 412: Subacute Inhalation Toxicity: 28-Day Study
OCDE
This revised Test Guideline 412 (TG 412) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a limited period of time (28 days), and to provide data for quantitative inhalation risk ...
    08 sep 2009 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9741301e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-413-subchronic-inhalation-toxicity-90-day-study_9789264070806-en
  • LIRE
Test No. 413: Subchronic Inhalation Toxicity: 90-day Study
OCDE
This revised Test Guideline has been designed to fully characterize test article toxicity by the inhalation route for a subchronic duration (90 days), and to provide robust data for quantitative inhalation risk assessments. Groups of 10 male and 10 ...
    08 sep 2009 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9745101e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-451-carcinogenicity-studies_9789264071186-en
  • LIRE
Test No. 451: Carcinogenicity Studies
OCDE
The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses of a test substance by an appropriate route of ...
    08 sep 2009 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9745201e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-452-chronic-toxicity-studies_9789264071209-en
  • LIRE
Test No. 452: Chronic Toxicity Studies
OCDE
The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both ...
    08 sep 2009 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9745301e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-453-combined-chronic-toxicity-carcinogenicity-studies_9789264071223-en
  • LIRE
Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies
OCDE
The objective of a combined chronic toxicity/carcinogenicity study is to identify carcinogenic and the majority of chronic effects, and to determine dose-response relationships following prolonged and repeated exposure. The rat is typically used for ...
    08 sep 2009 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9743601e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-436-acute-inhalation-toxicity-acute-toxic-class-method_9789264076037-en
  • LIRE
Test No. 436: Acute Inhalation Toxicity – Acute Toxic Class Method
OCDE
The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according to the Globally Harmonized System of ...
    08 sep 2009 Test No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants
OCDE
The Bovine Corneal Opacity and Permeability test method (BCOP) is an in vitro test method that can be used to classify substances as 'ocular corrosives and severe irritants'. The BCOP uses isolated corneas from the eyes of cattle slaughtered for ...
    08 sep 2009 Test No. 438: Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants
OCDE
The Isolated Chicken Eye (ICE) test method is an in vitro test method that can be used to classify substances as "ocular corrosives and severe irritants". The ICE method uses eyes collected from chickens obtained from slaughterhouses where they are ...
    08 sep 2009 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9744101e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-441-hershberger-bioassay-in-rats_9789264076334-en
  • LIRE
Test No. 441: Hershberger Bioassay in Rats
OCDE
The Hershberger Bioassay is an in vivo short–term screening test. It evaluates the ability of a chemical to elicit biological activities consistent with androgen agonists, antagonists or 5 á-reductase inhibitors. The current bioassay is based on the ...
    08 sep 2009 Test No. 455: The Stably Transfected Human Estrogen Receptor-alpha Transcriptional Activation Assay for Detection of Estrogenic Agonist-Activity of Chemicals
OCDE
This Test Guideline describes an in vitro assay, which provides mechanistical information, and can be used for screening and prioritization purposes. The test system utilises the hERalpha-HeLa-9903 cell line derived from a human cervical tumor and ...
    16 oct 2008 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9740701e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-407-repeated-dose-28-day-oral-toxicity-study-in-rodents_9789264070684-en
  • LIRE
Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents
OCDE
This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The method is based on the repeated oral administration of the substance of interest during one limited period (one dose level ...
    16 oct 2008 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9742501e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-425-acute-oral-toxicity-up-and-down-procedure_9789264071049-en
  • LIRE
Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure
OCDE
The method permits estimation of an LD50 with a confidence interval and the results allow a substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling of chemicals. It is easiest to ...
    15 oct 2007 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9742601e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-426-developmental-neurotoxicity-study_9789264067394-en
  • LIRE
Test No. 426: Developmental Neurotoxicity Study
OCDE
A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...
    15 oct 2007 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9744001e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-440-uterotrophic-bioassay-in-rodents_9789264067417-en
  • LIRE
Test No. 440: Uterotrophic Bioassay in Rodents
OCDE
The Uterotrophic Bioassay is an in vivo short-term screening test. It is based on the increase in uterine weight or uterotrophic response. The Uterotrophic Bioassay relies for its sensitivity on an animal test system in which the ...
    11 sep 2006 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9740001e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/summary-of-considerations-in-the-report-from-the-oecd-expert-groups-on-short-term-and-long-term-toxicology_9789264035447-en
  • LIRE
Summary of Considerations in the Report from the OECD Expert Groups on Short Term and Long Term Toxicology
OCDE
    17 août 2006 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9743501e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-435-in-vitro-membrane-barrier-test-method-for-skin-corrosion_9789264067318-en
  • LIRE
Test No. 435: In Vitro Membrane Barrier Test Method for Skin Corrosion
OCDE
This Test Guideline is for an in vitro membrane barrier test method that can be used to identify corrosive substances. The test method utilizes an artificial membrane designed to respond to corrosive substances in a manner similar to animal skin in ...
    23 nov 2004 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9742701e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-427-skin-absorption-in-vivo-method_9789264071063-en
  • LIRE
Test No. 427: Skin Absorption: In Vivo Method
OCDE
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
    23 nov 2004 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9742801e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-428-skin-absorption-in-vitro-method_9789264071087-en
  • LIRE
Test No. 428: Skin Absorption: In Vitro Method
OCDE
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...
    23 nov 2004 Test No. 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER)
OCDE
The Globally Harmonised System for the Classification and Labelling of Chemicals defines skin corrosion as the production of irreversible tissue damage in the skin following the application of a test material. The test material (150 µL for liquids ...
    23 nov 2004 Test No. 431: In Vitro Skin Corrosion: Human Skin Model Test
OCDE
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using ...
    23 nov 2004 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9743201e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-432-in-vitro-3t3-nru-phototoxicity-test_9789264071162-en
  • LIRE
Test No. 432: In Vitro 3T3 NRU Phototoxicity Test
OCDE
This Test Guideline describes a method to evaluate photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light. Balb/c 3T3 cells are maintained in culture for 24 h for formation ...
    24 avr 2002 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9740401e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-404-acute-dermal-irritation-corrosion_9789264070622-en
  • LIRE
Test No. 404: Acute Dermal Irritation/Corrosion
OCDE
This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. This Test Guideline recommends sequential testing strategies, which include the performance of validated and ...
    24 avr 2002 Test No. 405: Acute Eye Irritation/Corrosion
OCDE
This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is ...
    08 fév 2002 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9742001e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-420-acute-oral-toxicity-fixed-dose-procedure_9789264070943-en
  • LIRE
Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure
OCDE
A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...
    08 fév 2002 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9742301e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-423-acute-oral-toxicity-acute-toxic-class-method_9789264071001-en
  • LIRE
Test No. 423: Acute Oral toxicity - Acute Toxic Class Method
OCDE
This is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class Method.
    22 jan 2001 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9741401e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-414-prenatal-development-toxicity-study_9789264070820-en
  • LIRE
Test No. 414: Prenatal Development Toxicity Study
OCDE
This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...
    22 jan 2001 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9741601e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-416-two-generation-reproduction-toxicity_9789264070868-en
  • LIRE
Test No. 416: Two-Generation Reproduction Toxicity
OCDE
This Test Guideline for two-generation reproduction testing is designed to provide general information concerning the effects of a test substance on the integrity and performance of the male and female reproductive systems, and on the growth and ...
    21 sep 1998 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9740801e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-408-repeated-dose-90-day-oral-toxicity-study-in-rodents_9789264070707-en
  • LIRE
Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents
OCDE
This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity ...
    21 sep 1998 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9740901e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-409-repeated-dose-90-day-oral-toxicity-study-in-non-rodents_9789264070721-en
  • LIRE
Test No. 409: Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents
OCDE
This method provides information on health hazard likely to arise from short-term exposure to test substance. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been ...
    21 jui 1997 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9742401e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-424-neurotoxicity-study-in-rodents_9789264071025-en
  • LIRE
Test No. 424: Neurotoxicity Study in Rodents
OCDE
This Test Guideline has been designed to obtain the information necessary to confirm or to further characterise the potential neurotoxicity of chemicals in adult animals. This Test Guideline is designed for use with the rat. It specifically ...
    21 jui 1997 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9747101e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-471-bacterial-reverse-mutation-test_9789264071247-en
  • LIRE
Test No. 471: Bacterial Reverse Mutation Test
OCDE
The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ...
    21 jui 1997 Test No. 473: In vitro Mammalian Chromosome Aberration Test
OCDE
The purpose of the in vitro chromosome aberration test is to identify agents that cause structural chromosome aberrations in cultured mammalian somatic cells. Structural aberrations may be of two types: chromosome or chromatid. The in vitro ...
    21 jui 1997 Test No. 474: Mammalian Erythrocyte Micronucleus Test
OCDE
The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood ...
    21 jui 1997 Test No. 475: Mammalian Bone Marrow Chromosome Aberration Test
OCDE
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters). Structural chromosome ...
    21 jui 1997 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9747601e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-476-in-vitro-mammalian-cell-gene-mutation-test_9789264071322-en
  • LIRE
Test No. 476: In vitro Mammalian Cell Gene Mutation Test
OCDE
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In the cell lines the most commonly-used genetic endpoints measure mutation at thymidine kinase (TK) and hypoxanthine-guanine ...
    21 jui 1997 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9748301e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-483-mammalian-spermatogonial-chromosome-aberration-test_9789264071469-en
  • LIRE
Test No. 483: Mammalian Spermatogonial Chromosome Aberration Test
OCDE
This test measures chromosome events in spermatogonial germ cells and is, therefore, expected to be predictive of induction of inheritable mutations in germ cells. Male Chinese hamsters and mice are commonly used. Animals are exposed to the test ...
    21 jui 1997 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9748601e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-486-unscheduled-dna-synthesis-uds-test-with-mammalian-liver-cells-in-vivo_9789264071520-en
  • LIRE
Test No. 486: Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo
OCDE
The purpose of the unscheduled DNA synthesis (UDS) test with mammalian liver cells in vivo is to identify substances that induce DNA repair after excision and removal of a stretch of DNA containing a region of damage induced by chemical substances ...
    22 mars 1996 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9742201e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-422-combined-repeated-dose-toxicity-study-with-the-reproduction-developmental-toxicity-screening-test_9789264070981-en
  • LIRE
Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test
OCDE
The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks; females should be dosed throughout the study (approximately 54 days). Normally, matings "one male to one ...
    27 jui 1995 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9741801e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-418-delayed-neurotoxicity-of-organophosphorus-substances-following-acute-exposure_9789264070905-en
  • LIRE
Test No. 418: Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure
OCDE
The test substance is administered orally in a single dose to domestic hens. The animals are observed for 21 days, then the remainder of the hens are killed and histopathological examination is undertaken. The young adult domestic laying hen (Gallus ...
    27 jui 1995 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9741901e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-419-delayed-neurotoxicity-of-organophosphorus-substances-28-day-repeated-dose-study_9789264070929-en
  • LIRE
Test No. 419: Delayed Neurotoxicity of Organophosphorus Substances: 28-day Repeated Dose Study
OCDE
This Test Guideline is used in the assessment and evaluation of the toxic effects of organophosporus substances. Daily doses of the test substance are administered orally (preferably by gavage or administration of gelatin capsules) to domestic ...
    27 jui 1995 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9742101e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-421-reproduction-developmental-toxicity-screening-test_9789264070967-en
  • LIRE
Test No. 421: Reproduction/Developmental Toxicity Screening Test
OCDE
The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 54 days. This Test Guideline is designed ...
    17 jui 1992 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9740601e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-406-skin-sensitisation_9789264070660-en
  • LIRE
Test No. 406: Skin Sensitisation
OCDE
This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application. In this Test Guideline, the methods preferred over other are: the Guinea Pig Maximisation ...
    24 fév 1987 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9740101e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-401-acute-oral-toxicity_9789264040113-en
  • LIRE
Test No. 401: Acute Oral Toxicity
OCDE
The OECD Guidelines for the Testing of Chemicals are a collection of about 100 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of ...
    24 fév 1987 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9740201e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-402-acute-dermal-toxicity_9789264070585-en
  • LIRE
Test No. 402: Acute Dermal Toxicity
OCDE
This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ...
    23 oct 1986 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9747901e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-479-genetic-toxicology-in-vitro-sister-chromatid-exchange-assay-in-mammalian-cells_9789264071384-en
  • LIRE
Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells
OCDE
The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...
    23 oct 1986 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9748001e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-480-genetic-toxicology-saccharomyces-cerevisiae-gene-mutation-assay_9789264071407-en
  • LIRE
Test No. 480: Genetic Toxicology: Saccharomyces cerevisiae, Gene Mutation Assay
OCDE
This assay may be used to measure gene mutation in yeast, a eukaryotic micro-organism. Strains of Saccharomyces cerevisiae have been developed which detect forward or reverse mutations. A variety of haploid and diploid strains of the yeast can be ...
    23 oct 1986 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9748101e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-481-genetic-toxicology-saacharomyces-cerevisiae-miotic-recombination-assay_9789264071421-en
  • LIRE
Test No. 481: Genetic Toxicology: Saacharomyces cerevisiae, Miotic Recombination Assay
OCDE
This assay may be used to measure mitotic recombination (gene conversion or crossingover) in yeast, a eukaryotic micro-organism. Crossing-over is generally assayed by the production of recessive homozygous colonies or sectors produced in a ...
    23 oct 1986 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9748201e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-482-genetic-toxicology-dna-damage-and-repair-unscheduled-dna-synthesis-in-mammalian-cells-in-vitro_9789264071445-en
  • LIRE
Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro
OCDE
The Test Guideline for Unscheduled DNA Synthesis (UDS) in mammalian cells in vitro describes procedures utilizing primary cultures, human lymphocytes or established cell lines, to detect DNA repair synthesis after excision and removal of a stretch ...
    23 oct 1986 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9748401e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-484-genetic-toxicology-mouse-spot-test_9789264071483-en
  • LIRE
Test No. 484: Genetic Toxicology: Mouse Spot Test
OCDE
The mouse spot test detects presumed somatic mutations in fetal cells following transplacental absorption of the test substance. This is an in vivo test in mice in which developing embryos are exposed to a chemical (solid, liquid, vapour or ...
    23 oct 1986 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9748501e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-485-genetic-toxicology-mouse-heritable-translocation-assay_9789264071506-en
  • LIRE
Test No. 485: Genetic toxicology, Mouse Heritable Translocation Assay
OCDE
The mouse heritable translocation test detects structural and numerical chromosome changes in mammalian germ cells as recovered in first generation progeny. The types of chromosome changes detected in this test system are reciprocal translocations ...
    04 avr 1984 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9747701e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-477-genetic-toxicology-sex-linked-recessive-lethal-test-in-drosophila-melanogaster_9789264071346-en
  • LIRE
Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster
OCDE
Mutations in the X-chromosome of Drosophila melanogaster are phenotypically expressed in males carrying the mutant gene. When the mutation is lethal in the hemizygous condition, its presence is inferred from the absence of one class of male ...
    04 avr 1984 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9747801e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-478-genetic-toxicology-rodent-dominant-lethal-test_9789264071360-en
  • LIRE
Test No. 478: Genetic Toxicology: Rodent Dominant Lethal Test
OCDE
Dominant lethal (DL) effects cause embryonic or foetal death. Induction of a dominant lethal event after exposure to a test substance (liquid, solid, vapour or gas, …) indicates that the substance has affected germinal tissue of the test species ...
    26 mai 1983 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9741501e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-415-one-generation-reproduction-toxicity-study_9789264070844-en
  • LIRE
Test No. 415: One-Generation Reproduction Toxicity Study
OCDE
This Test Guideline for reproduction testing is designed to provide general information concerning the effects of a test substance (Solid, liquid, gas or vapour) on male and female reproductive performance. The test substance is administered orally ...
    12 mai 1981 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9741001e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-410-repeated-dose-dermal-toxicity-21-28-day-study_9789264070745-en
  • LIRE
Test No. 410: Repeated Dose Dermal Toxicity: 21/28-day Study
OCDE
This study relates to the analysis, via dermal application, of the health hazard of solid or liquid test substance. This method is composed of two tests: the main test and the limit test. This Test Guideline is intended for use with the adult rat ...
    12 mai 1981 Cliquez pour accéder: 
    http://oecd.metastore.ingenta.com/content/9741101e.pdf
  • PDF
  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/test-no-411-subchronic-dermal-toxicity-90-day-study_9789264070769-en
  • LIRE
Test No. 411: Subchronic Dermal Toxicity: 90-day Study
OCDE
This study relates to the analysis, via dermal application, of the health hazards of solid or liquid test substance. It may be carried out after initial information obtained by acute testing. This method is composed of the main test and the limit ...
Ajouter à ma sélection