OECD Guidelines for the Testing of Chemicals, Section 5

Other Test Guidelines

ISSN :
2074-5796 (online)
DOI :
10.1787/20745796
Hide / Show Abstract

The OECD Guidelines for the Testing of Chemicals is a collection of about 100 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of new and existing chemical substances, chemical preparations and chemical mixtures. They are a set of tools for professionals, used primarily in regulatory safety testing and subsequent chemical and chemical product notification and chemical registration. They can also be used for the selection and ranking of candidate chemicals during the development of new chemicals and products and in toxicology research. This group of tests covers other test guidelines.

Also available in: French
 
Test No. 507: Nature of the Pesticide Residues in Processed Commodities - High Temperature Hydrolysis

Test No. 507: Nature of the Pesticide Residues in Processed Commodities - High Temperature Hydrolysis You or your institution have access to this content

Click to Access: 
Author(s):
OECD
Publication Date :
15 Oct 2007
Pages :
15
ISBN :
9789264067431 (PDF)
DOI :
10.1787/9789264067431-en

Hide / Show Abstract

This Test Guideline describes a method conducted as model studies to predict the degradation pathway of the active ingredient under hydrolytic conditions, to identify the degradation products, and to determine the relative amount of degradation products.

Three representative hydrolysis conditions should be investigated. Radiolabelled active test substance are used to elucidate the possible degradation pathway and for quantitation of the extent of degradation. The use of tritium (3H) as a label is not permitted due to the possibility of hydrogen exchange with the water. The proposed value for the concentration of a water soluble active ingredient in the studies required here is 1.0 mg/L. Samples may be analysed directly by chromatography or may be extracted with a series of solvents or solvent mixtures with various polarities and other characteristics depending on the nature of the expected residues. The characterisation and identification of extractable residues is made. Ideally samples should be stored at/or below -18°C. The report should include the routes of degradation observed, the degradation pathway, the composition of total radioactive residues, the limit of quantification for radioactivity determination and chromatographic separation.

Also available in: French