OECD Guidelines for the Testing of Chemicals, Section 1

Physical-Chemical properties

2074-5753 (online)
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The OECD Guidelines for the Testing of Chemicals is a collection of about 150 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of chemicals. They are a set of tools for professionals, used primarily in regulatory safety testing and subsequent chemical and chemical product notification, chemical registration and in chemical evaluation. They can also be used for the selection and ranking of candidate chemicals during the development of new chemicals and products and in toxicology research. This group of tests covers physical-chemical properties.

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Test No. 113: Screening Test for Thermal Stability and Stability in Air

Test No. 113: Screening Test for Thermal Stability and Stability in Air You or your institution have access to this content

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12 May 1981
9789264069749 (PDF)

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This Test Guideline describes methods for determining storage stability of a substance with respect to heat and air. Two methods are applicable to homogeneous solid and liquid substances and to mixtures of these: the accelerated storage test and the thermal analysis methods.

In the accelerated storage test (CIPAC), a long duration storage instability can be simulated by applying a higher temperature during a short test. This test calls for the controlled storage at 54°C to 55°C for 14 days and subsequent analysis. In simple cases, it will be enough to determine a characteristic property before and after storage. The substance is considered to be stable at room temperature if the melting point has remained constant or the content of original substance as determined by analysis has decreased by not more than 5 per cent.

In the thermal analysis methods (TGA and DTA), the sample and the standard reference material are heated up to the final temperature at a constant rate in a defined test atmosphere, either separately in a TGA or DTA apparatus, or in a combined system. The weight change of the sample or the quantities of heat absorbed or given off are measured and recorded. The substance is considered to be stable at room temperature if no decomposition or chemical transformation is found below 150°.

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