OECD Guidelines for the Testing of Chemicals, Section 1
Physical-Chemical properties
- ISSN :
- 2074-5753 (online)
- DOI :
- 10.1787/20745753
The OECD Guidelines for the Testing of Chemicals is a collection of about 100 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of new and existing chemical substances, chemical preparations and chemical mixtures. They are a set of tools for professionals, used primarily in regulatory safety testing and subsequent chemical and chemical product notification and chemical registration. They can also be used for the selection and ranking of candidate chemicals during the development of new chemicals and products and in toxicology research. This group of tests covers physical-chemical properties.
Test No. 105: Water Solubility
- Publication Date :
- 27 July 1995
- Pages :
- 7
- ISBN :
- 9789264069589 (PDF)
- DOI :
- 10.1787/9789264069589-en
This Test Guideline describes methods to determine the water solubility of test substances. The water solubility of a substance is the saturation mass concentration of the substance in water at a given temperature. This guideline addresses the determination of the solubility in water of essentially pure substances which are stable in water and not volatile. Before determining water solubility, it is useful to have some preliminary information on the substance, like structural formula, vapour pressure, dissociation constant and hydrolysis as a function of pH.
The column elution method and the flask method which cover respectively solubilities below and above 10-2 g/l are described. The test is preferably run at 20 ± 0,5 °C. A simple preliminary test is allowed to determine approximately the appropriate amount of sample to be used in the final test, as well as the time necessary to achieve saturation.