This document captures and examines schemes used internationally for prioritising chemicals for risk assessment and/or risk management, and identifies commonalities, differences, lessons learned and areas for improvement. Based on this analysis it...

This document is intended to provide universal Guiding Principles that should be considered when developing or augmenting systematic approaches to Weight of Evidence (WoE) for chemical evaluation and Key Elements to formulating a systematic approach...

This document describes good practices for the licensing of protected elements included in OECD Test Guidelines (TGs). Transparency and communication are needed around protected elements resulting from innovation in sciences and techniques that are...

The IUCLID (International Uniform ChemicaL Information Database) can be customised to manage chemical data in different contexts and is a platform employing globally harmonised data elements pertinent to chemicals. The version 6 of IUCLID software...

The report outlines the technical aspects of the various approaches and methodologies available with respect to the assessment of risks from combined exposures to multiple chemicals. The document draws from approaches applied and experience gained in...

In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing,...

This document suggests an Integrated Approach on Testing and Assessment (IATA) for serious eye damage and eye irritation hazard identification. The document also provides key information characteristics of each of the individual information sources...

The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part of Integrated Approaches for Testing and Assessment (IATA). However, there...

Several models, tools and methods have been published in the past 20 years to include bioavailability in risk assessment and several OECD member countries already have developed frameworks and published guidance documents for taking metal...

With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides guidance on the reporting of defined approaches to testing...

With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides a set of principles for reporting defined approaches to...

OECD member countries have been making efforts to expand the use of alternative methods in assessing chemicals. The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and...

Following a general update of the Genetic Toxicology TGs in 2015, the present Document was written to provide succinct and useful information to individuals unfamiliar with genetic toxicology testing, as well as experienced individuals wishing to...

Acute toxicity tests are an area of focus for developing alternative assays and approaches to address animal welfare concerns. In the context of this document, acute toxicity studies refer to studies involving a single exposure to a test chemical and...

This document presents a harmonized method for characterising, for assessment purposes, a specific subcategory of UVCBs (Substances of Unknown or Variable composition, Complex reaction products or Biological materials): hydrocarbon solvent...

In this document the importance of mechanistic consideration in quantitative structure-activity relationship ((Q)SAR) analysis, the critical role of mechanistic consideration in improving various (Q)SAR approaches and possible integrative approaches...

This document is a report of the Workshop on a framework for the development and use of integrated approaches to testing and assessment which was held on 17-19 November 2014 in Crystal City VA, USA. This framework should provide guiding principles,...

In this document a strategy is presented to facilitate the ecological risk assessment of organometallic compounds (OM) and organic metal salts (OMS), outlining key steps that are based on elucidation of the fate of these substances in the...

The purpose of this guidance is to harmonise the way non-guideline in vitro methods are described and thereby facilitate an assessment of the relevance of test methods for biological activities and responses of interest, and an assessment of the...

This scoping document aims at bringing forward relevant in vitro and ex vivo thyroid assays to the attention of OECD member countries, to provide recommendations for their development/use, and also, to identify aspects/blocks of the thyroid...