OECD Series on Adverse Outcome Pathways

Adverse Outcome Pathway on binding of agonists to ionotropic glutamate receptors in adult brain leading to excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment
ISSN: 
2415-170X (online)
http://dx.doi.org/10.1787/2415170X
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An Adverse Outcome Pathway (AOP) describes a logical sequence of causally linked events at different levels of biological organisation, which follows exposure to a chemical and leads to an adverse health effect in humans or wildlife. AOPs are the central element of a toxicological knowledge framework, promoted by member countries through OECD, built to support chemical risk assessment based on mechanistic reasoning. These AOPs are available in the AOP Wiki, an interactive and virtual encyclopaedia for AOP development. Following their development and review, the endorsed AOPs are published the OECD Series on Adverse Outcome Pathways. As scientific knowledge progresses, the publication of an AOP in this series does not preclude the regular update or new contributions to a given AOP in the AOP Wiki. While the AOP Wiki is a dynamic tool, only impactful changes to the AOP will be reflected in subsequent updates of the published AOP. The number 1 in the OECD Series on Adverse Outcome Pathways is the Users’ Handbook, which is a supplement to the Guidance Document for developing and assessing AOPs. This handbook contains an updated template for AOP development and provides focused and practical instructions for both AOP developers and reviewers.
 
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  N° 6   09 Sep 2016
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    http://oecd.metastore.ingenta.com/content/5jlr8vqgm630-en.pdf
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  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/adverse-outcome-pathway-on-binding-of-agonists-to-ionotropic-glutamate-receptors-in-adult-brain-leading-to-excitotoxicity-that-mediates-neuronal-cell-death-contributing-to-learning-and-memory-impairment_5jlr8vqgm630-en
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Adverse Outcome Pathway on binding of agonists to ionotropic glutamate receptors in adult brain leading to excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment
Magdalini Sachana, Sharon Munn, Anna Bal-Price
Under physiological conditions activation of glutamate ionotropic receptors such as N-methyl-D-aspartate (NMDARs), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPARs) and kainate (KARs) is responsible for basal excitatory synaptic...
  N° 5   13 Aug 2016
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    http://oecd.metastore.ingenta.com/content/5jlsqs5hcrmq-en.pdf
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  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/adverse-outcome-pathway-on-chronic-binding-of-antagonist-to-n-methyl-d-aspartate-receptors-nmdars-during-brain-development-induces-impairment-of-learning-and-memory-abilities_5jlsqs5hcrmq-en
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Adverse Outcome Pathway on chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
Magdalini Sachana, Sharon Munn, Anna Bal-Price
It is well documented and accepted that learning and memory processes rely on physiological functioning of the glutamate receptor N-methyl-D-aspartate (NMDAR). Both animal and human studies investigating NMDA itself, experiments with NMDAR...
  N° 4   06 Aug 2016
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    http://oecd.metastore.ingenta.com/content/5jlsv05mx433-en.pdf
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  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/adverse-outcome-pathway-on-aromatase-inhibition-leading-to-reproductive-dysfunction-in-fish_5jlsv05mx433-en
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Adverse Outcome Pathway on Aromatase Inhibition Leading to Reproductive Dysfunction (in Fish)
Dan Villeneuve
This adverse outcome pathway details the linkage between inhibition of gonadal aromatase activity in females and reproductive dysfunction, as measured through the adverse effect of reduced cumulative fecundity and spawning. Initial development of...
  N° 3   04 Aug 2016
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    http://oecd.metastore.ingenta.com/content/5jlsvvxn1zjc-en.pdf
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  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/adverse-outcome-pathway-on-alkylation-of-dna-in-male-pre-meiotic-germ-cells-leading-to-heritable-mutations_5jlsvvxn1zjc-en
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Adverse Outcome Pathway on Alkylation of DNA in Male Pre-Meiotic Germ Cells Leading to Heritable Mutations
Carole Yauk, Iain Lambert, Francesco Marchetti, George Douglas
Germ cell/heritable mutations are important regulatory endpoints for international agencies interested in protecting the health of future generations. However, germ cell mutation analysis has been hampered by a lack of efficient tools. The motivation...
  N° 2   04 Aug 2016
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    http://oecd.metastore.ingenta.com/content/5jlsvwl6g7r5-en.pdf
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  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/adverse-outcome-pathway-on-protein-alkylation-leading-to-liver-fibrosis_5jlsvwl6g7r5-en
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Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis
Brigitte Landesmann
Liver fibrosis is an important human health issue associated with chemical exposure. It is a typical result of chronic toxic injury and one of the considered endpoints for regulatory purposes. This AOP describes the linkage between hepatic injury...
  N° 1   28 July 2016
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    http://oecd.metastore.ingenta.com/content/5jlv1m9d1g32-en.pdf
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  • http://www.keepeek.com/Digital-Asset-Management/oecd/environment/users-handbook-supplement-to-the-guidance-document-for-developing-and-assessing-adverse-outcome-pathways_5jlv1m9d1g32-en
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Users' Handbook supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways
OECD
This document is a supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways (AOPs). It provides focused and practical instructions for both AOP developers and reviewers and is intended to assist in identifying,...
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