1887
  1. Home
  2. Papers
  3. OECD Series on Adverse Outcome Pathways
  4. Adverse Outcome Pathway on Aromatase Inhibition Leading to Reproductive Dysfunction (in Fish)

OECD Series on Adverse Outcome Pathways

An Adverse Outcome Pathway (AOP) describes a logical sequence of causally linked events at different levels of biological organisation, which follows exposure to a stressor and leads to an adverse health effect in humans or wildlife. AOPs are the central element of a toxicological knowledge framework, promoted by member countries through OECD, built to support chemical risk assessment based on mechanistic reasoning. These AOPs are available in the AOP-Wiki, an interactive and virtual encyclopaedia for AOP development. Following their development and review, the endorsed AOPs are published in the OECD Series on Adverse Outcome Pathways. As scientific knowledge progresses, the publication of an AOP in this series does not preclude regular updates or new contributions to a given AOP. While the AOP-Wiki is a dynamic tool, only impactful changes to the AOP will be reflected in subsequent updates of the published AOP.

More

English

Adverse Outcome Pathway on Aromatase Inhibition Leading to Reproductive Dysfunction (in Fish)

This adverse outcome pathway details the linkage between inhibition of gonadal aromatase activity in females and reproductive dysfunction, as measured through the adverse effect of reduced cumulative fecundity and spawning. Initial development of this AOP draws heavily on evidence collected using repeat-spawning fish species. Cumulative fecundity is the most apical endpoint considered in the OECD 229 Fish Short Term Reproduction Assay. The OECD 229 assay serves as screening assay for endocrine disruption and associated reproductive impairment (OECD 2012). Cumulative fecundity is one of several variables known to be of demographic significance in forecasting fish population trends. Therefore, this AOP has utility in supporting the application of measures of aromatase, or in silico predictions of the ability to inhibit aromatase, as a means to identify chemicals with known potential to adversely affect fish populations and potentially other oviparous vertebrates.
Less

English

Keywords: repeat-spawning fish species, Fish Short Term Reproduction Assay, reproductive toxicity, aromatase inhibition, reduced cumulative fecundity
EMAIL THIS PAGE

Author(s)
Daniel L. Villeneuvei iUS Environmental Protection Agency (EPA)

06 Aug 2016

50 pages

No. 4

https://doi.org/10.1787/5jlsv05mx433-en

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error